I am interested in applying novel imaging modalities for investigating biological specimens. In particular, this includes high speed imaging for understanding the dynamics of networks of excitable cells (e.g cardiac and neural tissue) and the development of methods for fluorescence imaging at low light levels.
Temporal Pixel Multiplexing (TPM) is a new imaging modality that controls camera exposure at the pixel level to embed temporal information in static images. We have implemented TPM in the lab using DMD micromirror arrays and an off-the-shelf CCD for mapping voltage and calcium transients in cardiac tissue. This can be achieved at kilohertz rates even with a slow scan, low noise camera.